VGLL4 Gene Summary [Human]
Predicted to enable transcription coactivator binding activity. Involved in negative regulation of Wnt signaling pathway; negative regulation of cell growth; and negative regulation of hippo signaling. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | VGLL4 |
| Official Name | vestigial like family member 4 [Source:HGNC Symbol;Acc:HGNC:28966] |
| Ensembl ID | ENSG00000144560 |
| Bio databases IDs | |
| Aliases | vestigial like family member 4 |
| Synonyms | KIAA0121, vestigial-like family member 4, VGL-4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human VGLL4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Short repeats in human TONDU, fly vestigial and other proteins
- TDU motif
- protein binding
- Transcription cofactor vestigial-like protein 4
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- epithelial cancer
- epithelial neoplasia
- cholangiocarcinoma cancer
- liver cancer
- bile duct cancer
- liver neoplasia
- biliary tract cancer
- abdominal cancer
role in cell
- expression in
- proliferation
- phosphorylation in
- binding in
- growth
- production in
- migration
- degradation in
- damage in
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human VGLL4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cardiac muscle cell proliferation
- negative regulation of hippo signaling cascade
- negative regulation of transcription, DNA-dependent
- negative regulation of cell growth
- positive regulation of protein catabolic process
- negative regulation of Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator binding