Vgll4 Gene Summary [Mouse]
Predicted to enable transcription coactivator binding activity. Involved in negative regulation of cardiac muscle cell proliferation; negative regulation of hippo signaling; and regulation of primary metabolic process. Located in nucleus. Is expressed in lung; submandibular gland primordium; tooth; and vibrissa. Orthologous to human VGLL4 (vestigial like family member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Vgll4 |
| Official Name | vestigial like family member 4 [Source:MGI Symbol;Acc:MGI:2652840] |
| Ensembl ID | ENSMUSG00000030315 |
| Bio databases IDs | |
| Aliases | vestigial like family member 4 |
| Synonyms | KIAA0121, vestigial-like family member 4, VGL-4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vgll4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Short repeats in human TONDU, fly vestigial and other proteins
- TDU motif
- protein binding
- Transcription cofactor vestigial-like protein 4
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- epithelial cancer
- epithelial neoplasia
- cholangiocarcinoma cancer
- liver cancer
- bile duct cancer
- liver neoplasia
- biliary tract cancer
- abdominal cancer
role in cell
- expression in
- proliferation
- phosphorylation in
- binding in
- growth
- production in
- migration
- degradation in
- damage in
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vgll4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cardiac muscle cell proliferation
- negative regulation of hippo signaling cascade
- negative regulation of transcription, DNA-dependent
- negative regulation of cell growth
- positive regulation of protein catabolic process
- negative regulation of Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator binding