DGKQ Gene Summary [Human]
The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | DGKQ |
| Official Name | diacylglycerol kinase theta [Source:HGNC Symbol;Acc:HGNC:2856] |
| Ensembl ID | ENSG00000145214 |
| Bio databases IDs | |
| Aliases | diacylglycerol kinase theta |
| Synonyms | DAGK, DAGK4, DAGK7, Dgkd, Dgk theta, Dgk δ, DGK θ, diacylglycerol kinase theta, diacylglycerol kinase, theta, diacylglycerol kinase θ, diacylglycerol kinase, θ |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DGKQ often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- diacylglycerol kinase
- enzyme binding
- transcription factor binding
- protein binding
- Diacylglycerol kinase catalytic domain (presumed)
- kinase
- lipid kinase, YegS/Rv2252/BmrU family
- transmembrane receptor protein tyrosine kinase activator
- kinase binding
- receptor tyrosine kinase binding
- Diacylglycerol kinase accessory domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- Ubl1_cv_Nsp3_N-like
- Diacylglycerol kinase catalytic domain
- protein kinase C
- cysteine rich domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- insulin-dependent diabetes mellitus
- primary biliary cirrhosis
- systemic lupus erythematosus
- myositis
- Sjögren syndrome
- systemic sclerosis
- limited systemic sclerosis
role in cell
- binding in
- activation
- endocytosis
- response by
- signaling in
- gluconeogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- glutaminergic synapse
- cytoskeleton
- presynaptic regions
- cell periphery
- perinuclear region
- postsynaptic region
- Nucleus
- Plasma Membrane
- endosomes
- cytosol
- vesicle membrane
- nucleoli
- nuclear speckles
- nuclear matrix
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DGKQ gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of progesterone biosynthetic process
- protein kinase C signaling cascade
- regulation of cortisol biosynthetic process
- response to cAMP
- diacylglycerol metabolic process
- lipid phosphorylation
- glycerolipid metabolic process
- platelet activation
- positive regulation of peptidyl-tyrosine phosphorylation
- intracellular signal transduction
- G-protein coupled receptor signaling pathway
- response to ATP
- regulation of synaptic vesicle endocytosis
- regulation of gluconeogenesis
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- regulation of G-protein coupled receptor protein signaling pathway
- protein kinase C-activating G-protein coupled receptor signaling pathway
- phosphatidic acid biosynthetic process
- regulation of transcription from RNA polymerase II promoter
- regulation of cholesterol metabolic process
- negative regulation of gene expression
- thrombin receptor signaling pathway
- negative regulation of peptidyl-threonine phosphorylation
- positive regulation of gene expression
- peptidyl-serine phosphorylation
- cAMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- nucleus
- endosome
- cytoskeleton
- cytoplasm
- nuclear speck
- vesicle membrane
- cytosol
- nuclear matrix
- nucleolus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- phospholipase binding
- transmembrane receptor protein tyrosine kinase activator activity
- diacylglycerol kinase activity
- alkylglycerol kinase activity
- kinase binding