HAVCR2 Gene Summary [Human]
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]
Details
| Type | Protein Coding |
| Official Symbol | HAVCR2 |
| Official Name | hepatitis A virus cellular receptor 2 [Source:HGNC Symbol;Acc:HGNC:18437] |
| Ensembl ID | ENSG00000135077 |
| Bio databases IDs | |
| Aliases | hepatitis A virus cellular receptor 2, T-cell immunoglobulin mucin family member 3 |
| Synonyms | CD366, hepatitis A virus cellular receptor 2, KIM-3, SPTCL, TIM-3, TIM3 receptor, TIMD-3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HAVCR2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Immunoglobulin V-Type
- immunoglobulin domain
- transmembrane domain
- Immunoglobulin like
- mucin domain
- protein binding
- Src-homology 2 binding domain
- Immunoglobulin V-set domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the HAVCR2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- asthma
- psoriatic arthritis
- metastatic non-squamous non-small cell lung cancer
- multiple sclerosis
- rheumatoid arthritis
- infection
- experimental autoimmune encephalomyelitis
- advanced non-squamous non-small cell lung cancer
- hyperplasia
role in cell
- expression in
- phosphorylation in
- binding in
- quantity
- growth
- apoptosis
- production in
- degradation in
- proliferation
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cilia
- cell surface
- cellular membrane
- immunological synapses
- early endosomes
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HAVCR2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- toll-like receptor 7 signaling pathway
- macrophage activation involved in immune response
- inflammatory response
- negative regulation of interleukin-2 production
- positive regulation of macrophage activation
- positive regulation of interferon-gamma production
- negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
- negative regulation of granulocyte colony-stimulating factor production
- natural killer cell tolerance induction
- positive regulation of tumor necrosis factor production
- positive regulation of chemokine production
- negative regulation of interferon-gamma production
- negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
- negative regulation of tumor necrosis factor production
- negative regulation of myeloid dendritic cell activation
- negative regulation of interferon-alpha production
- defense response to Gram-positive bacterium
- toll-like receptor 9 signaling pathway
- maternal process involved in female pregnancy
- negative regulation of NF-kappaB transcription factor activity
- adaptive immune response
- positive regulation of T cell proliferation
- negative regulation of defense response to bacterium
- regulation of transcription from RNA polymerase II promoter
- regulation of tolerance induction dependent upon immune response
- positive regulation of defense response to bacterium
- negative regulation of interleukin-6 production
- negative regulation of gene expression
- negative regulation of natural killer cell activation
- cellular response to lipopolysaccharide
- negative regulation of T cell proliferation
- innate immune response
- positive regulation of ERK1 and ERK2 cascade
- negative regulation of immunological synapse formation
- negative regulation of T-helper 1 type immune response
- toll-like receptor 3 signaling pathway
- negative regulation of interleukin-3 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-1 production
Cellular Component
Where in the cell the gene product is active
- early endosome
- anchoring junction
- mediator complex
- immunological synapse
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding