SFRP2 Gene Summary [Human]
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SFRP2 |
| Official Name | secreted frizzled related protein 2 [Source:HGNC Symbol;Acc:HGNC:10777] |
| Ensembl ID | ENSG00000145423 |
| Bio databases IDs | |
| Aliases | secreted frizzled related protein 2 |
| Synonyms | FRP-2, SARP1, SDF-5, secreted frizzled-related protein 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SFRP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt-protein binding
- Fz domain
- protein binding
- enzyme regulator activity
- protease activator
- enzyme activator activity
- fibronectin binding
- CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
- NTR_like
- integrin binding
- receptor agonist activity
- transmembrane receptor
- cysteine rich domain
Pathways
Biological processes and signaling networks where the SFRP2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- edema
- neoplasia
- epithelial cancer
- adenoma formation
- liver cancer
- HER2 negative hormone receptor negative breast cancer
- androgenic alopecia
- syndactyly
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- formation
- apoptosis
- growth
- expression in
- differentiation
- survival
- cell death
- proliferation
- formation in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Extracellular Space
- extracellular matrix
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SFRP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sclerotome development
- planar cell polarity pathway involved in neural tube closure
- male gonad development
- negative regulation of planar cell polarity pathway involved in axis elongation
- positive regulation of fat cell differentiation
- positive regulation of angiogenesis
- embryonic digit morphogenesis
- planar cell polarity pathway involved in axis elongation
- positive regulation of cell growth
- cardiac muscle cell apoptotic process
- negative regulation of transcription, DNA-dependent
- negative regulation of cell growth
- BMP signaling pathway
- regulation of stem cell division
- regulation of neuron projection development
- positive regulation of peptidyl-serine phosphorylation
- cell-cell signaling
- positive regulation of canonical Wnt receptor signaling pathway
- negative regulation of mesodermal cell fate specification
- response to nutrient
- mesodermal cell fate specification
- cardiac left ventricle morphogenesis
- negative regulation of gene expression
- cellular response to X-ray
- negative regulation of epithelial cell proliferation
- negative regulation of Wnt receptor signaling pathway
- negative regulation of cardiac muscle cell apoptotic process
- negative regulation of cell migration
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- outflow tract morphogenesis
- chondrocyte development
- response to xenobiotic stimulus
- positive regulation of osteoblast differentiation
- positive regulation of transcription from RNA polymerase II promoter
- convergent extension involved in axis elongation
- negative regulation of epithelial to mesenchymal transition
- patterning of blood vessels
- canonical Wnt receptor signaling pathway
- positive regulation of cell adhesion mediated by integrin
- negative regulation of peptidyl-tyrosine phosphorylation
- negative regulation of dermatome development
- Wnt receptor signaling pathway involved in somitogenesis
- stem cell fate specification
- digestive tract morphogenesis
- negative regulation of BMP signaling pathway
- negative regulation of canonical Wnt receptor signaling pathway
- positive regulation of apoptotic process
- hemopoietic stem cell proliferation
- collagen fibril organization
- non-canonical Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- endopeptidase activator activity
- fibronectin binding
- integrin binding
- receptor agonist activity
- Wnt-protein binding