MAP3K11 Gene Summary [Human]
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MAP3K11 |
| Official Name | mitogen-activated protein kinase kinase kinase 11 [Source:HGNC Symbol;Acc:HGNC:6850] |
| Ensembl ID | ENSG00000173327 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase kinase 11 |
| Synonyms | 2610017K16RIK, MEKK11, mitogen-activated protein kinase kinase kinase 11, MLK-3, PTK1, RHOE, SPRK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAP3K11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTPase binding domain
- glycine rich domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- protein kinase binding
- ATP-binding domain
- Protein tyrosine and serine/threonine kinase
- ATP binding
- JUN kinase kinase kinase
- enzyme binding
- leucine zipper domain
- protein binding
- Protein kinase domain
- identical protein binding
- MAP kinase kinase kinase
- proline rich domain
- Src Homology 3 domain superfamily
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- protein homodimerization
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the MAP3K11 gene in human plays a role, providing insight into its function and relevance in health or disease.
- B Cell Receptor Signaling
- CD27 Signaling in Lymphocytes
- Cdc42 Signaling
- G-Protein Coupled Receptor Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- GNRH Signaling
- HGF Signaling
- IL-15 Production
- Integrin Signaling
- Natural Killer Cell Signaling
- NGF Signaling
- PKCθ Signaling in T Lymphocytes
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Rac Signaling
- RANK Signaling in Osteoclasts
- Reelin Signaling in Neurons
- SAPK/JNK Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Signaling by Rho Family GTPases
- Sperm Motility
- STAT3 Pathway
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- neoplasia
- epithelial cancer
- liver cancer
- mammary neoplasm
- hepatocellular carcinoma
- gout
- Moyamoya disease
- infection by HIV-1
role in cell
- apoptosis
- colony formation by
- expression in
- invasion by
- cell viability
- migration
- proliferation
- growth
- phosphorylation in
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- centrosome
- microtubules
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAP3K11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- positive regulation of JUN kinase activity
- positive regulation of JNK cascade
- positive regulation of apoptotic process
- protein autophosphorylation
- JNK cascade
- protein phosphorylation
- positive regulation of neuron apoptotic process
- microtubule-based process
Cellular Component
Where in the cell the gene product is active
- centrosome
- membrane
- cytosol
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- protein homodimerization activity
- JUN kinase kinase kinase activity
- small GTPase binding
- protein kinase activity
- MAP kinase kinase kinase activity
- mitogen-activated protein kinase kinase kinase binding
- protein serine/threonine kinase activity
- mitogen-activated protein kinase kinase binding