NKD2 Gene Summary [Human]
This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Details
| Type | Protein Coding |
| Official Symbol | NKD2 |
| Official Name | NKD inhibitor of WNT signaling pathway 2 [Source:HGNC Symbol;Acc:HGNC:17046] |
| Ensembl ID | ENSG00000145506 |
| Bio databases IDs | |
| Aliases | NKD inhibitor of WNT signaling pathway 2, naked cuticle-2, Dvl-binding protein NKD2 |
| Synonyms | 2210403L10Rik, AW212591, mNkd2, Naked2, naked cuticle 2, NKD inhibitor of WNT signaling pathway 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NKD2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- myosin binding
- ubiquitin protein ligase binding
- ATPase binding
- protein binding
- growth factor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- papillary thyroid carcinoma
- papillary thyroid cancer
- organismal death
- lung metastasis
- thyroid carcinoma
- epithelial thyroid cancer
role in cell
- expression in
- proliferation
- migration
- invasion by
- store-operated calcium influx in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- exocytic vesicle
- cell periphery
- Plasma Membrane
- basolateral membrane
- lateral plasma membrane
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NKD2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Golgi vesicle fusion to target membrane
- negative regulation of canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway
- positive regulation of protein processing
- negative regulation of Wnt receptor signaling pathway
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- exocytosis
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- exocytic vesicle
- lateral plasma membrane
- cytoplasm
- cytoplasmic vesicle
- basolateral plasma membrane
- plasma membrane
- cell periphery
Molecular Function
What the gene product does at the molecular level
- growth factor binding
- ubiquitin protein ligase binding
- protein binding
- calcium ion binding
- myosin heavy chain binding
- ATPase binding
- binding, bridging