C1qtnf2 Gene Summary [Mouse]
Enables identical protein binding activity and signaling receptor binding activity. Involved in regulation of lipid metabolic process. Acts upstream of or within positive regulation of D-glucose import; positive regulation of MAPK cascade; and positive regulation of small molecule metabolic process. Located in extracellular space. Part of protein-containing complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and skeleton. Orthologous to human C1QTNF2 (C1q and TNF related 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | C1qtnf2 |
| Official Name | C1q and tumor necrosis factor related protein 2 [Source:MGI Symbol;Acc:MGI:1916433] |
| Ensembl ID | ENSMUSG00000046491 |
| Bio databases IDs | |
| Aliases | C1q and tumor necrosis factor related protein 2 |
| Synonyms | 1810033K05RIK, Adih, C1q and TNF related 2, C1q and tumor necrosis factor related protein 2, C1q and tumour necrosis factor related protein 2, Complement-c1q tnf-related protein 2 homolog, CTRP2, RGD1561041, zacrp2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse C1qtnf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Collagen triple helix repeat (20 copies)
- protein binding
- receptor binding
- identical protein binding
- C1q domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- PKA
- ERK1/2
- triacylglycerol
- D-glucose
- cholesterol
- HDL/cholesterol
- oxygen
- MGLL
- LDL/cholesterol
- 18:2(9Z,12Z)/18:2(9Z,12Z) phosphatidylethanolamine
disease
- obesity
- rotator cuff injury
phenotypes
- increased prepulse inhibition
- prolonged PQ interval
- prolonged PR interval
- abnormal PQ interval
- abnormal liver physiology
- abnormal phospholipid level
- abnormal prepulse inhibition
- decreased body fat mass
- decreased body weight
- decreased cholesterol level
- decreased circulating HDL cholesterol level
- decreased circulating LDL cholesterol level
- decreased circulating cholesterol level
- decreased epididymal fat pad weight
- decreased inguinal fat pad weight
- decreased lean body mass
- decreased liver cholesterol level
- decreased liver triglyceride level
- decreased respiratory quotient
- decreased white adipose tissue amount
- enhanced lipolysis
- increased basal metabolism
- increased carbon dioxide production
- increased circulating VLDL cholesterol level
- increased circulating VLDL triglyceride level
- increased circulating free fatty acid level
- increased circulating glycerol level
- increased circulating triglyceride level
- increased energy expenditure
- increased oxygen consumption
- small liver
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse C1qtnf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of lipid metabolic process
Cellular Component
Where in the cell the gene product is active
- collagen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding