ARHGAP18 Gene Summary [Human]
Enables GTPase activator activity. Involved in several processes, including regulation of actin filament polymerization; regulation of small GTPase mediated signal transduction; and small GTPase mediated signal transduction. Located in cytosol; nuclear speck; and plasma membrane. Part of cytoplasmic microtubule and ruffle. Implicated in schizophrenia. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ARHGAP18 |
| Official Name | Rho GTPase activating protein 18 [Source:HGNC Symbol;Acc:HGNC:21035] |
| Ensembl ID | ENSG00000146376 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 18 |
| Synonyms | 4833419J07Rik, bA307O14.2, LOC100363197, MacGAP, Rho GTPase activating protein 18, SENEX |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARHGAP18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- GTPase activator
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- schizophrenia
- primary myelofibrosis
role in cell
- expression in
- apoptosis
- formation
- polymerization
- organization
- transmigration
- stress-induced premature senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ruffle
- Plasma Membrane
- microtubules
- cytosol
- nuclear speckles
- Weibel-Palade bodies
- cytoplasmic microtubule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARHGAP18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of actin filament polymerization
- regulation of cell shape
- regulation of actin cytoskeleton organization
- regulation of small GTPase mediated signal transduction
- small GTPase mediated signal transduction
- regulation of cell motility
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- nuclear speck
- ruffle
- cytosol
- cytoplasmic microtubule
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- cadherin binding
- GTPase activator activity