Arhgap18 Gene Summary [Mouse]
Enables GTPase activator activity. Predicted to be involved in several processes, including regulation of actin filament polymerization; regulation of small GTPase mediated signal transduction; and small GTPase-mediated signal transduction. Predicted to be located in several cellular components, including cytoplasmic microtubule; nuclear speck; and ruffle. Predicted to be active in cytoplasm. Is expressed in lower leg bone. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human ARHGAP18 (Rho GTPase activating protein 18). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgap18 |
| Official Name | Rho GTPase activating protein 18 [Source:MGI Symbol;Acc:MGI:1921160] |
| Ensembl ID | ENSMUSG00000039031 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 18 |
| Synonyms | 4833419J07Rik, bA307O14.2, LOC100363197, MacGAP, Rho GTPase activating protein 18, SENEX |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arhgap18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- GTPase activator
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- schizophrenia
- primary myelofibrosis
role in cell
- expression in
- apoptosis
- formation
- polymerization
- organization
- transmigration
- stress-induced premature senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ruffle
- Plasma Membrane
- microtubules
- cytosol
- nuclear speckles
- Weibel-Palade bodies
- cytoplasmic microtubule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arhgap18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of actin filament polymerization
- regulation of cell shape
- regulation of actin cytoskeleton organization
- regulation of small GTPase mediated signal transduction
- small GTPase mediated signal transduction
- regulation of cell motility
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- nuclear speck
- ruffle
- cytosol
- cytoplasmic microtubule
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- cadherin binding
- GTPase activator activity