SHPRH Gene Summary [Human]
SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | SHPRH |
| Official Name | SNF2 histone linker PHD RING helicase [Source:HGNC Symbol;Acc:HGNC:19336] |
| Ensembl ID | ENSG00000146414 |
| Bio databases IDs | |
| Aliases | SNF2 histone linker PHD RING helicase |
| Synonyms | 2610103K11Rik, bA545I5.2, D230017O13Rik, E130018M05, RAD5, SNF2 histone linker PHD RING helicase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SHPRH often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- PHD zinc finger
- H15
- ubiquitin protein ligase activity
- SNF2-related domain
- helicase superfamily c-terminal domain
- enzyme
- Ring finger domain
- protein binding
- Helicase conserved C-terminal domain
- linker histone H1 and H5 family
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- PHD finger superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SHPRH gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- protein polyubiquitination
- response to DNA damage stimulus
- nucleosome assembly
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- ubiquitin-protein ligase activity
- DNA binding
- ubiquitin protein ligase binding
- protein binding
- metal ion binding
- helicase activity
- hydrolase activity