MTA3 Gene Summary [Human]
Predicted to enable histone deacetylase binding activity; transcription coactivator activity; and transcription corepressor activity. Involved in negative regulation of transcription, DNA-templated. Located in nucleoplasm. Part of NuRD complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MTA3 |
| Official Name | metastasis associated 1 family member 3 [Source:HGNC Symbol;Acc:HGNC:23784] |
| Ensembl ID | ENSG00000057935 |
| Bio databases IDs | |
| Aliases | metastasis associated 1 family member 3 |
| Synonyms | 1110002J22RIK, hCG 1783907, LOC100130921, metastasis associated 1 family member 3, metastasis associated 1 family, member 3, metastasis associated 3, mKIAA1266, MTA1 family member 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MTA3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SANT
- BAH domain
- BAH
- transcription regulator
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- ELM2 domain
- binding protein
- Myb-like DNA-binding domain
- MTA R1 domain
- zinc finger binding to DNA consensus sequence [AT]GATA[AG]
- protein binding
- ZnF_GATA
Pathways
Biological processes and signaling networks where the MTA3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- B cell cancer
- insomnia
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- prostate cancer
- attention deficit hyperactivity disorder
- plasma cell neoplasm
- mature B-cell neoplasia
role in cell
- proliferation
- expression in
- production in
- survival
- fate determination
- remodeling
- G2/M phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MTA3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- regulation of cell fate specification
- G2/M transition of mitotic cell cycle
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- regulation of stem cell differentiation
- positive regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- NuRD complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone deacetylase binding
- transcription coactivator activity
- transcription corepressor activity
- metal ion binding
- sequence-specific DNA binding
- chromatin binding