SLC22A3 Gene Summary [Human]
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SLC22A3 |
| Official Name | solute carrier family 22 member 3 [Source:HGNC Symbol;Acc:HGNC:10967] |
| Ensembl ID | ENSG00000146477 |
| Bio databases IDs | |
| Aliases | solute carrier family 22 member 3, organic cation transporter 3, extraneuronal monoamine transporter |
| Synonyms | EMT, EMTH, OCT3, Orct3, Slca22a3, solute carrier family 22 member 3, solute carrier family 22 (organic cation transporter), member 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC22A3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dopamine:sodium symporter
- benzoate transport
- MFS transporter, sugar porter (SP) family
- Multidrug resistance protein
- Major Facilitator Superfamily
- phosphate:H+ symporter
- neurotransmitter transporter
- protein binding
- organic anion transporter
- organic cation transporter
- monoamine transporter
- Sugar (and other) transporter
- spermidine transporter
- toxin transporter
- cation transport protein
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- prostate cancer
- epithelial cancer
- cancer
- peptic ulcer disease
- acute myocardial infarction
- prostatic carcinoma
- peripheral arterial disease
- coronary artery disease
- esophageal adenocarcinoma
role in cell
- accumulation in
- survival
- transport in
- neurotoxicity in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endomembrane system
- Cytoplasm
- cellular membrane
- basolateral cell surfaces
- apical membrane
- basolateral membrane
- mitochondrial membrane
- cellular protrusions
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC22A3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- norepinephrine transport
- quaternary ammonium group transport
- dopamine transport
- organic cation transport
- regulation of appetite
- histamine transport
- histamine metabolic process
- norepinephrine uptake
- serotonin uptake
- neurotransmitter transport
- epinephrine transport
- ion transport
- serotonin transport
- purine-containing compound transmembrane transport
- monocarboxylic acid transport
- spermidine transport
- xenobiotic transport
- histamine uptake
- epinephrine uptake
- monoamine transport
- organic anion transport
Cellular Component
Where in the cell the gene product is active
- mitochondrial membrane
- membrane
- endomembrane system
- nuclear outer membrane
- neuronal cell body
- basolateral plasma membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- neurotransmitter transporter activity
- quaternary ammonium group transmembrane transporter activity
- organic cation transmembrane transporter activity
- protein binding
- spermidine transmembrane transporter activity
- monoamine transmembrane transporter activity
- toxin transporter activity
- organic anion transmembrane transporter activity