PDLIM2 Gene Summary [Human]
This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | PDLIM2 |
| Official Name | PDZ and LIM domain 2 [Source:HGNC Symbol;Acc:HGNC:13992] |
| Ensembl ID | ENSG00000120913 |
| Bio databases IDs | |
| Aliases | PDZ and LIM domain 2, mystique |
| Synonyms | 4732462F18RIK, MYSTIQUE, PDZ and LIM domain 2, SLIM |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PDLIM2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Domain present in PSD-95, Dlg, and ZO-1/2
- myosin binding
- cytoskeletal protein binding
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- actinin binding
- alpha helix
- canonical PDZ domain
- protein binding
- PDZ domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- Parkinson disease
- infection by bacteria
role in cell
- binding
- colony formation
- activation in
- growth
- expression in
- migration
- invasion by
- function
- binding in
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- cortical actin cytoskeleton
- cytoskeleton
- focal adhesions
- Nucleus
- actin stress fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PDLIM2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- protein catabolic process
- muscle structure development
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- Z disc
- nucleus
- adherens junction
- stress fiber
- filamentous actin
- cortical actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- ubiquitin protein ligase binding
- protein binding
- actin binding
- metal ion binding
- myosin heavy chain binding
- muscle alpha-actinin binding
- filamin binding