CDCA5 Gene Summary [Human]
Predicted to enable chromatin binding activity. Involved in double-strand break repair; mitotic sister chromatid segregation; and regulation of cell cycle process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CDCA5 |
| Official Name | cell division cycle associated 5 [Source:HGNC Symbol;Acc:HGNC:14626] |
| Ensembl ID | ENSG00000146670 |
| Bio databases IDs | |
| Aliases | cell division cycle associated 5, sororin |
| Synonyms | 2610036L13RIK, cell division cycle associated 5, LOC256676, MGC16386, RGD1560863, SORORIN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDCA5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- Sororin protein
- chromatin binding
- protein binding
- ERK phosphorylation site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- prostate cancer
- colorectal cancer
- liver cancer
- cardiovascular disorder
- prostatic adenocarcinoma
- uterine cancer
- renal cell cancer
role in cell
- apoptosis
- proliferation
- cell death
- phosphorylation in
- growth
- number
- cohesion
- chromosomal congression
- cohesion in
- maintenance in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- chromosome
- nucleoplasm
- centromeres
- synaptonemal complexes
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDCA5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- positive regulation of exit from mitosis
- mitotic chromosome condensation
- mitotic sister chromatid cohesion
- mitotic metaphase plate congression
- mitotic cell cycle
- double-strand break repair
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- chromosome
- chromosome, centromeric region
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- chromatin binding