WAPL Gene Summary [Human]
Involved in several processes, including negative regulation of DNA replication; negative regulation of chromatin binding activity; and regulation of sister chromatid cohesion. Located in several cellular components, including Golgi apparatus; intercellular bridge; and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | WAPL |
| Official Name | WAPL cohesin release factor [Source:HGNC Symbol;Acc:HGNC:23293] |
| Ensembl ID | ENSG00000062650 |
| Bio databases IDs | |
| Aliases | WAPL cohesin release factor, friend of EBNA2 |
| Synonyms | A530089A20Rik, DIF-2, FOE, HWAPL, KIAA0261, RGD1308960, WAPAL, WAPL cohesin release factor |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WAPL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wings apart-like protein regulation of heterochromatin
- enzyme
- protein binding
- DNA dependent ATPase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- migraines
- squamous-cell carcinoma
- squamous cell cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- cervical intraepithelial neoplasia
role in cell
- proliferation
- condensation
- expression in
- cell death
- invasion by
- migration
- quantity
- binding
- cell cycle progression
- aneuploidization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- cytoplasmic bridges
- cytosol
- chromosome
- nucleoplasm
- mitotic spindle
- centromeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human WAPL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- negative regulation of chromatin binding
- protein localization to chromatin
- mitotic sister chromatid segregation
- negative regulation of sister chromatid cohesion
- negative regulation of DNA replication
Cellular Component
Where in the cell the gene product is active
- nucleus
- intercellular bridge
- mitotic spindle
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- chromosome
- chromosome, centromeric region
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding