CUL9 Gene Summary [Human]
Predicted to enable several functions, including ATP binding activity; metal ion binding activity; and ubiquitin protein ligase binding activity. Involved in microtubule cytoskeleton organization; protein ubiquitination; and regulation of mitotic nuclear division. Located in cytosol. Part of cullin-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | CUL9 |
| Official Name | cullin 9 [Source:HGNC Symbol;Acc:HGNC:15982] |
| Ensembl ID | ENSG00000112659 |
| Bio databases IDs | |
| Aliases | cullin 9, parkin-like cytoplasmic p53 binding protein, p53-associated parkin-like cytoplasmic protein |
| Synonyms | 1810035I07Rik, cullin 9, H7-AP1, mKIAA0708, PARC, RGD1562008 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CUL9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IBR domain, a half RING-finger domain
- ubiquitin protein ligase activity
- APC10-like
- Cullin protein neddylation domain
- BRcat_Rcat_RBR
- enzyme
- Mouse development and cellular proliferation protein Cullin-7
- protein binding
- cullin homology domain
- In Between Ring fingers
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- p53-binding domain
- Cullin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- schizophrenia
- insomnia
- tumorigenesis
- lymphomagenesis
- head and neck neuroendocrine neoplasia
- head and neck neoplasia
- hematologic cancer
- lymphoid cancer
role in cell
- apoptosis
- ubiquitination in
- accumulation in
- degradation in
- cell viability
- quantity
- morphology
- autophagy in
- damage in
- immortalization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CUL9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitosis
- microtubule cytoskeleton organization
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cullin-RING ubiquitin ligase complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- zinc ion binding
- ubiquitin protein ligase binding
- protein binding