TSPYL2 Gene Summary [Human]
This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009]
Details
| Type | Retained Intron |
| Official Symbol | TSPYL2 |
| Official Name | TSPY like 2 [Source:HGNC Symbol;Acc:HGNC:24358] |
| Ensembl ID | ENSG00000184205 |
| Bio databases IDs | |
| Aliases | TSPY like 2 |
| Synonyms | CDA1, CINAP, CTCL, DENTT, DXBwg1396e, DXHXS1008E, E130307F10Rik, HRIHFB2216, NP79, RGD1563283, SE204, TSPX, TSPY-like 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TSPYL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nucleosome assembly protein (NAP)
- PTZ00007
- nuclear localization sequence
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-small cell lung cancer
- endometrium tumor
role in cell
- growth
- colony formation
- density
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TSPYL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein kinase activity
- negative regulation of cell growth
- negative regulation of cell cycle
- negative regulation of DNA replication
- regulation of signal transduction
- nucleosome assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone binding
- rDNA binding
- chromatin binding