DOK2 Gene Summary [Human]
The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | DOK2 |
| Official Name | docking protein 2 [Source:HGNC Symbol;Acc:HGNC:2991] |
| Ensembl ID | ENSG00000147443 |
| Bio databases IDs | |
| Aliases | docking protein 2, downstream of tyrosine kinase 2 |
| Synonyms | Doc2, docking protein 2, DokR, Frip, p56DOK, p56dok-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DOK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- proline-methionine-methionine-proline motif
- PTB domain (IRS-1 type)
- proline and tyrosine-rich region
- Rasgap binding domain
- PH domain
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- transmembrane receptor protein tyrosine kinase adaptor protein
- proline-glutamic acid-serine-proline motif
- proline-glycine-alanine-proline motif
- Nck-binding domain
Pathways
Biological processes and signaling networks where the DOK2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- atopic dermatitis
- splenomegaly
- pancreatic epithelial cancer
- tumorigenesis
- leukemia
- androgenic alopecia
- lung cancer
- myeloproliferative disorder
- diabetes mellitus
role in cell
- migration
- proliferation
- development
- phosphorylation in
- cell viability
- invasion by
- quantity
- function
- number
- transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DOK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- transmembrane receptor protein tyrosine kinase signaling pathway
- cell surface receptor signaling pathway
- Ras protein signal transduction
- positive regulation of MAPK cascade
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- transmembrane receptor protein tyrosine kinase adaptor activity