DOCK5 Gene Summary [Human]
This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family act as guanine nucleotide exchange factors for small Rho family G proteins. The protein encoded by this gene is thought to associate with adaptors CRK and CRKL, and function in regulation of intestinal epithelial cell spreading and migration on collagen IV. Similar proteins in mouse and zebrafish also function in myoblast fusion. [provided by RefSeq, Oct 2016]
Details
| Type | Protein Coding |
| Official Symbol | DOCK5 |
| Official Name | dedicator of cytokinesis 5 [Source:HGNC Symbol;Acc:HGNC:23476] |
| Ensembl ID | ENSG00000147459 |
| Bio databases IDs | |
| Aliases | dedicator of cytokinesis 5 |
| Synonyms | 1110060D06RIK, BC016533, dedicator of cytokinesis 5, E130320D18, LOC286061, lr2, rlc |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DOCK5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DHR-2, Lobe B
- C2 domain in Dock180 and Zizimin proteins
- DHR-2, Lobe A
- DOCK N-terminus
- protein binding
- proline rich domain
- Src Homology 3 domain superfamily
- Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins
- C-terminal proline-rich domain
- guanyl-nucleotide exchange factor
- DOCK homology region 2
- C2 domain
- DHR-2, Lobe C
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- metastasis
- uterine leiomyoma
- leiomyomatosis
- coronary artery disease
- inguinal hernia
- idiopathic scoliosis
- passive systemic anaphylaxis
- immunodeficiency
role in cell
- phosphorylation in
- proliferation
- expression in
- growth
- cell spreading
- binding in
- assembly
- assembly in
- formation
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- podosomes
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DOCK5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Rac protein signal transduction
- bone remodeling
- myoblast fusion
- positive regulation of epithelial cell migration
- positive regulation of substrate adhesion-dependent cell spreading
- cell migration
- podosome assembly
Cellular Component
Where in the cell the gene product is active
- anchoring junction
- cytoplasm
- cytosol
- cell projection
- plasma membrane
- podosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity
- guanyl-nucleotide exchange factor activity
- small GTPase binding