RNASEL Gene Summary [Human]
This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. The protein is involved in innate immunity and is active against multiple RNA viruses, including the influenza and SARS-CoV-2 viruses. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Nov 2021]
Details
| Type | Protein Coding |
| Official Symbol | RNASEL |
| Official Name | ribonuclease L [Source:HGNC Symbol;Acc:HGNC:10050] |
| Ensembl ID | ENSG00000135828 |
| Bio databases IDs | |
| Aliases | ribonuclease L |
| Synonyms | E230029I04Rik, HPC1, PRCA1, Ribonuclease L, ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent), RNASEL 80KD, RNS4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNASEL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ankyrin repeats (many copies)
- protein kinase
- rRNA binding
- Ankyrin repeats (3 copies)
- PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins
- enzyme
- protein binding
- 5' phosphomonoester producing endoribonuclease
- identical protein binding
- pseudo kinase domain
- Ankyrin repeat
- RNA binding
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Non-5' phosphomonoester producing endoribonuclease
- ribonuclease
- ribonucleoprotein binding
- RNase_Ire1_like
- ankyrin repeats
Pathways
Biological processes and signaling networks where the RNASEL gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neonatal late-onset sepsis
- ovarian cancer
- fibrosis
- hyperplasia
- demyelination
- hereditary prostate cancer 1
- pulmonary emphysema
- susceptibility to prostate cancer
- multiple sclerosis
- familial prostate cancer
role in cell
- survival
- expression in
- phosphorylation in
- cell death
- apoptosis
- production in
- proliferation
- activation in
- growth
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial fraction
- Mitochondria
- cytosol
- mitochondrial matrix
- nuclear matrix
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNASEL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- defense response to virus
- positive regulation of glucose import
- regulation of mRNA stability
- RNA processing
- mRNA processing
- fat cell differentiation
- rRNA processing
- positive regulation of transcription from RNA polymerase II promoter
- protein phosphorylation
- negative regulation of viral genome replication
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- cytosol
- nuclear matrix
Molecular Function
What the gene product does at the molecular level
- ATP binding
- RNA binding
- protein binding
- metal ion binding
- ribonucleoprotein complex binding
- ribonuclease activity
- protein kinase activity
- rRNA binding
- endoribonuclease activity