BLK Gene Summary [Human]
This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010]
Details
| Type | Protein Coding |
| Official Symbol | BLK |
| Official Name | BLK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:1057] |
| Ensembl ID | ENSG00000136573 |
| Bio databases IDs | |
| Aliases | BLK proto-oncogene, Src family tyrosine kinase |
| Synonyms | AC270286.1, BLK (MODY11), BLK proto-oncogene, Src family tyrosine kinase, B lymphoid kinase, MODY11, p55Blk |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BLK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- Src homology 2 (SH2) domain
- non-membrane spanning protein tyrosine kinase
- protein binding
- protein-tyrosine kinase
- Protein kinase domain
- Tyrosine kinase, catalytic domain
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the BLK gene in human plays a role, providing insight into its function and relevance in health or disease.
- Chronic Myeloid Leukemia Signaling
- Circadian Rhythm Signaling
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Ephrin A Signaling
- HER-2 Signaling in Breast Cancer
- IL-15 Production
- Maturity Onset Diabetes of Young (MODY) Signaling
- Opioid Signaling Pathway
- PI3K Signaling in B Lymphocytes
- Reelin Signaling in Neurons
- Role of Tissue Factor in Cancer
- Serotonin Receptor Signaling
- Sperm Motility
- Tec Kinase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- rheumatoid arthritis
- Sjögren syndrome
- systemic lupus erythematosus
- psoriatic arthritis
- cancer
- metastatic non-small cell lung cancer
- locally advanced non-small cell lung cancer
- metastatic non-squamous non-small cell lung cancer
- locally advanced nonsquamous non-small cell lung cancer
role in cell
- expression in
- apoptosis
- proliferation
- activation in
- phosphorylation in
- activation
- cell viability
- growth
- differentiation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- plasma
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BLK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine phosphorylation
- positive regulation of protein binding
- innate immune response
- cell differentiation
- transmembrane receptor protein tyrosine kinase signaling pathway
- positive regulation of insulin secretion
- protein phosphorylation
- intracellular signal transduction
- B cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein binding
- non-membrane spanning protein tyrosine kinase activity
- receptor binding