ZDHHC5 Gene Summary [Human]
Enables palmitoyltransferase activity. Involved in positive regulation of pattern recognition receptor signaling pathway and positive regulation of protein localization to plasma membrane. Acts upstream of or within protein palmitoylation. Located in phagocytic vesicle and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZDHHC5 |
| Official Name | zinc finger DHHC-type palmitoyltransferase 5 [Source:HGNC Symbol;Acc:HGNC:18472] |
| Ensembl ID | ENSG00000156599 |
| Bio databases IDs | |
| Aliases | zinc finger DHHC-type palmitoyltransferase 5, Zinc finger protein 375 |
| Synonyms | 1110032A17Rik, DHHC-5, zinc finger, DHHC domain containing 5, zinc finger DHHC-type palmitoyltransferase 5, Zisp, ZNF375 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZDHHC5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- palmitoyltransferase
- protein-cysteine S-palmitoleyltransferase
- DHHC palmitoyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- neoplasia
- pancreatic cancer
- neurotic disorder
- neuroticism
- lung adenocarcinoma
- lung adenocarcinoma formation
- depressive disorder
- schizophrenia
- major depression
role in cell
- phosphorylation in
- expression in
- proliferation
- phagocytosis
- phagocytosis by
- interaction in
- number
- colony formation
- palmitoylation in
- cell-cell adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- organelle
- postsynaptic region
- cellular membrane
- Plasma Membrane
- Golgi membrane
- nucleoplasm
- synapse
- axons
- dendrites
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZDHHC5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid transport
- innate immune response
- protein palmitoylation
- positive regulation of NLRP3 inflammasome complex assembly
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- dendrite
- membrane
- phagocytic vesicle
- Golgi membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein-cysteine S-palmitoleyltransferase activity
- protein binding
- palmitoyltransferase activity