RPP38 Gene Summary [Human]
Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Located in fibrillar center. Part of multimeric ribonuclease P complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RPP38 |
| Official Name | ribonuclease P/MRP subunit p38 [Source:HGNC Symbol;Acc:HGNC:30329] |
| Ensembl ID | ENSG00000152464 |
| Bio databases IDs | |
| Aliases | ribonuclease P/MRP subunit p38 |
| Synonyms | C330006A15RIK, ribonuclease P/MRP 38 subunit, ribonuclease P/MRP subunit p38 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RPP38 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
- ribonuclease P
- enzyme
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- nucleolar region
- nucleoplasm
- nucleoli
- coiled body
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RPP38 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rRNA processing
- tRNA 5'-leader removal
Cellular Component
Where in the cell the gene product is active
- ribonuclease MRP complex
- multimeric ribonuclease P complex
- nucleolus
- fibrillar center
- nucleolar ribonuclease P complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ribonuclease P activity
- protein binding
- ribonuclease P RNA binding