POP4 Gene Summary [Human]

This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to the nucleus and associates directly with the RNA component of these complexes. This protein is involved in processing of precursor RNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

Details

Type
Protein Coding
Official Symbol
POP4
Official Name
POP4 homolog, ribonuclease P/MRP subunit [Source:HGNC Symbol;Acc:HGNC:30081]
Ensembl ID
ENSG00000105171
Bio databases IDs NCBI: 10775 Ensembl: ENSG00000105171
Aliases POP4 homolog, ribonuclease P/MRP subunit
Synonyms 1110023P21Rik, POP4 homolog, ribonuclease P/MRP subunit, processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae), RPP29
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POP4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Ribonuclease P/MRP, subunit p29
  • ribonuclease P
  • enzyme
  • protein binding
  • POP4
  • RNA binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • hypertension
  • organismal death
  • colorectal cancer

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nucleolar region
  • dense fibrillar component
  • nucleoplasm
  • nucleoli
  • coiled body

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human POP4 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • rRNA processing
  • tRNA 5'-leader removal

Cellular Component

Where in the cell the gene product is active
  • ribonuclease MRP complex
  • multimeric ribonuclease P complex
  • nucleolus
  • ribonuclease P complex
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • ribonuclease P activity
  • protein binding
  • ribonuclease P RNA binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.