TRIM36 Gene Summary [Human]
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TRIM36 |
| Official Name | tripartite motif containing 36 [Source:HGNC Symbol;Acc:HGNC:16280] |
| Ensembl ID | ENSG00000152503 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 36, zinc-binding protein Rbcc728, tripartite motif protein 36, RING finger protein 98 |
| Synonyms | ANPH, ANPH1, D18Wsu100e, HAPRIN, RBCC728, RNF98, tripartite motif-containing 36 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM36 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- B-Box C-terminal domain
- SPRY domain
- TRIM C-terminal subgroup One Signature domain
- enzyme
- protein binding
- Fibronectin type 3 domain
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- FN3
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- alpha-tubulin binding
- B-box zinc finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial thyroid cancer
- thyroid carcinoma
- anencephaly
- anencephaly 1
- thoracic aortic aneurysm
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
role in cell
- expression in
- formation
- activation in
- degradation in
- cell cycle progression
- innate immune response in
- K48 polyubiquitination in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- Plasma Membrane
- microtubules
- cytosol
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM36 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spindle organization
- regulation of microtubule cytoskeleton organization
- acrosome reaction
- cytokinesis after mitosis
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytoplasm
- acrosomal vesicle
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding
- protein binding
- alpha-tubulin binding