ADGRA3 Gene Summary [Human]
This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2012]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | ADGRA3 |
| Official Name | adhesion G protein-coupled receptor A3 [Source:HGNC Symbol;Acc:HGNC:13839] |
| Ensembl ID | ENSG00000152990 |
| Bio databases IDs | |
| Aliases | adhesion G protein-coupled receptor A3 |
| Synonyms | 3830613O22RIK, adhesion G protein-coupled receptor A3, GPR125, PGR21, TEM5L, Tem5-like |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADGRA3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- 7 transmembrane receptor (Secretin family)
- immunoglobulin domain
- Immunoglobulin I-set domain
- Leucine rich repeat
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- Leucine Rich repeats (2 copies)
- seven-transmembrane G protein-coupled receptor superfamily
- Immunoglobulin like
- GPCR proteolysis site, GPS, motif
Pathways
Biological processes and signaling networks where the ADGRA3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive retinitis pigmentosa
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- retinitis pigmentosa
- idiopathic scoliosis
- alcoholic liver disease
regulates
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ADGRA3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- cell surface receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity