Adgra3 Gene Summary [Mouse]
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in cell surface receptor signaling pathway. Located in external side of plasma membrane. Is expressed in several structures, including central nervous system; craniocervical region bone; inner ear; limb; and metanephros. Orthologous to human ADGRA3 (adhesion G protein-coupled receptor A3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adgra3 |
| Official Name | adhesion G protein-coupled receptor A3 [Source:MGI Symbol;Acc:MGI:1917943] |
| Ensembl ID | ENSMUSG00000029090 |
| Bio databases IDs | |
| Aliases | adhesion G protein-coupled receptor A3 |
| Synonyms | 3830613O22RIK, adhesion G protein-coupled receptor A3, GPR125, PGR21, TEM5L, Tem5-like |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adgra3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- 7 transmembrane receptor (Secretin family)
- immunoglobulin domain
- Immunoglobulin I-set domain
- Leucine rich repeat
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- Leucine Rich repeats (2 copies)
- seven-transmembrane G protein-coupled receptor superfamily
- Immunoglobulin like
- GPCR proteolysis site, GPS, motif
Pathways
Biological processes and signaling networks where the Adgra3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive retinitis pigmentosa
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- retinitis pigmentosa
- idiopathic scoliosis
- alcoholic liver disease
regulates
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adgra3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- cell surface receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity