CDYL Gene Summary [Human]
Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed. The Y-linked genes arose by retrotransposition of an mRNA from this gene, followed by amplification of the retroposed gene. Proteins encoded by this gene superfamily possess a chromodomain, a motif implicated in chromatin binding and gene suppression, and a catalytic domain believed to be involved in histone acetylation. Multiple proteins are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CDYL |
| Official Name | chromodomain Y like [Source:HGNC Symbol;Acc:HGNC:1811] |
| Ensembl ID | ENSG00000153046 |
| Bio databases IDs | |
| Aliases | chromodomain Y like, CDY-like, autosomal, testis-specific chromodomain Y-like protein |
| Synonyms | CDYL1, chromodomain protein, Y chromosome-like, chromodomain Y-like, LOC361237 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDYL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Chromatin organization modifier domain
- histone binding
- transcription regulator
- crotonase-like
- transcription co-repressor
- protein binding activity, bridging
- chromatin binding
- enzyme
- protein binding
- identical protein binding
- CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
- 3-hydroxyacyl-CoA dehydratase
- Chromo (CHRromatin organization MOdifier) domain
- Enoyl-CoA hydratase/isomerase
Pathways
Biological processes and signaling networks where the CDYL gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- chromosome
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDYL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- random inactivation of X chromosome
- spermatid development
- spermatogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- chromosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription corepressor activity
- methylated histone residue binding
- chromatin binding
- protein binding, bridging