CMTM7 Gene Summary [Human]
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor that regulates G1/S transition in the cell cycle, and epidermal growth factor receptor/protein kinase B signaling during tumor pathogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
Details
| Type | Protein Coding |
| Official Symbol | CMTM7 |
| Official Name | CKLF like MARVEL transmembrane domain containing 7 [Source:HGNC Symbol;Acc:HGNC:19178] |
| Ensembl ID | ENSG00000153551 |
| Bio databases IDs | |
| Aliases | CKLF like MARVEL transmembrane domain containing 7 |
| Synonyms | CKLF-like MARVEL transmembrane domain containing 7, CKLFSF7, LNV |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CMTM7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Membrane-associating domain
- protein binding
- cytokine
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- hallux valgus
- idiopathic scoliosis
- venous thromboembolism
- vascular dementia
- herpes zoster
role in cell
- proliferation
- expression in
- phosphorylation in
- production in
- dexamethasone sensitivity
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CMTM7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- B-1a B cell differentiation
- signal transduction
Cellular Component
Where in the cell the gene product is active
- extracellular space
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytokine activity