RPIA Gene Summary [Human]
The protein encoded by this gene is an enzyme, which catalyzes the reversible conversion between ribose-5-phosphate and ribulose-5-phosphate in the pentose-phosphate pathway. This gene is highly conserved in most organisms. The enzyme plays an essential role in the carbohydrate metabolism. Mutations in this gene cause ribose 5-phosphate isomerase deficiency. A pseudogene is found on chromosome 18. [provided by RefSeq, Mar 2010]
Details
| Type | Protein Coding |
| Official Symbol | RPIA |
| Official Name | ribose 5-phosphate isomerase A [Source:HGNC Symbol;Acc:HGNC:10297] |
| Ensembl ID | ENSG00000153574 |
| Bio databases IDs | |
| Aliases | ribose 5-phosphate isomerase A, ribose 5-phosphate epimerase |
| Synonyms | ribose 5-phosphate isomerase A, RPI, Rpi1, RPIAD |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RPIA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SugarP_isomerase
- Ribose 5-phosphate isomerase A (phosphoriboisomerase A)
- ribose-5-phosphate isomerase
- monosaccharide binding
- enzyme
- protein binding
- carbohydrate binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RPIA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pentose-phosphate shunt, non-oxidative branch
- pentose-phosphate shunt
- D-ribose metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- monosaccharide binding
- ribose-5-phosphate isomerase activity