MPPE1 Gene Summary [Human]
Predicted to enable GPI anchor binding activity; GPI-mannose ethanolamine phosphate phosphodiesterase activity; and manganese ion binding activity. Involved in GPI anchor biosynthetic process. Located in Golgi apparatus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MPPE1 |
| Official Name | metallophosphoesterase 1 [Source:HGNC Symbol;Acc:HGNC:15988] |
| Ensembl ID | ENSG00000154889 |
| Bio databases IDs | |
| Aliases | metallophosphoesterase 1, post-GPI attachment to proteins 5 |
| Synonyms | Cdc1, metallophosphoesterase 1, PGAP5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MPPE1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding
- binding protein
- enzyme
- protein binding
- metallophosphatase superfamily, metallophosphatase domain
- manganese ion binding
- Calcineurin-like phosphoesterase superfamily domain
- phosphatidylinositol binding
- phosphoric diester hydrolase
- Calcineurin-like phosphoesterase
Pathways
Biological processes and signaling networks where the MPPE1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Endoplasmic Reticulum
- ER-to-Golgi intermediate compartment
- cis Golgi networks
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MPPE1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- GPI anchor biosynthetic process
- ER to Golgi vesicle-mediated transport
Cellular Component
Where in the cell the gene product is active
- cis-Golgi network
- endoplasmic reticulum exit site
- Golgi apparatus
- endoplasmic reticulum-Golgi intermediate compartment
- endoplasmic reticulum-Golgi intermediate compartment membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- manganese ion binding
- GPI anchor binding