TMEM39A Gene Summary [Human]
Involved in negative regulation of autophagosome assembly; negative regulation of autophagosome maturation; and positive regulation of viral genome replication. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | TMEM39A |
| Official Name | transmembrane protein 39A [Source:HGNC Symbol;Acc:HGNC:25600] |
| Ensembl ID | ENSG00000176142 |
| Bio databases IDs | |
| Aliases | transmembrane protein 39A, suppressor of SQST-1 aggregates in rpl-43 mutants |
| Synonyms | 2610033C09Rik, RGD1306421, SUSR2, transmembrane protein 39A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TMEM39A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Putative transmembrane protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TMEM39A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagy
- positive regulation of viral genome replication
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- protein binding