Vsig4 Gene Summary [Mouse]
Predicted to enable complement component C3b binding activity. Acts upstream of or within negative regulation of T cell proliferation and negative regulation of interleukin-2 production. Predicted to be part of protein-containing complex. Is expressed in bone marrow; oviduct; and thyroid gland. Orthologous to human VSIG4 (V-set and immunoglobulin domain containing 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vsig4 |
| Official Name | V-set and immunoglobulin domain containing 4 [Source:MGI Symbol;Acc:MGI:2679720] |
| Ensembl ID | ENSMUSG00000044206 |
| Bio databases IDs | |
| Aliases | V-set and immunoglobulin domain containing 4 |
| Synonyms | A530061A11, CRIg, V-set and immunoglobulin domain containing 4, Z39IG |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vsig4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- immunoglobulin variable region-like domain
- protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- atherosclerosis
- nonalcoholic fatty liver disease
- peripheral arterial disease
- epithelial cancer
- experimental autoimmune encephalomyelitis
- arthritis
- septic shock
- rheumatoid arthritis
role in cell
- killing
- expression in
- proliferation
- accumulation in
- quantity
- accumulation
- migration
- number
- function
- killing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intracellular space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vsig4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- complement activation, alternative pathway
- negative regulation of complement activation, alternative pathway
- negative regulation of interleukin-2 production
- negative regulation of macrophage activation
- negative regulation of T cell proliferation
Cellular Component
Where in the cell the gene product is active
- membrane
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- complement component C3b binding
- protein binding