OTOA Gene Summary [Human]
The protein encoded by this gene is specifically expressed in the inner ear, and is located at the interface between the apical surface of the inner ear sensory epithelia and their overlying acellular gels. It is prposed that this protein is involved in the attachment of the inner ear acellular gels to the apical surface of the underlying nonsensory cells. Mutations in this gene are associated with autosomal recessive deafness type 22 (DFNB22). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | OTOA |
| Official Name | otoancorin [Source:HGNC Symbol;Acc:HGNC:16378] |
| Ensembl ID | ENSG00000155719 |
| Bio databases IDs | |
| Aliases | otoancorin, cancer/testis antigen 108 |
| Synonyms | CT108, DFNB22, otoancorin, RGD1562741 |
| Species | Human, Homo sapiens |
| Orthologies |
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human OTOA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- cell-matrix adhesion
- transmission of nerve impulse
Cellular Component
Where in the cell the gene product is active
- extracellular region
- plasma membrane
- apical plasma membrane
- cell surface