DEPTOR Gene Summary [Human]
Involved in several processes, including negative regulation of TOR signaling; negative regulation of cell size; and negative regulation of protein kinase activity. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DEPTOR |
| Official Name | DEP domain containing MTOR interacting protein [Source:HGNC Symbol;Acc:HGNC:22953] |
| Ensembl ID | ENSG00000155792 |
| Bio databases IDs | |
| Aliases | DEP domain containing MTOR interacting protein |
| Synonyms | 4731402B04RIK, DEP.6, DEPDC6, DEP domain containing MTOR-interacting protein, FLJ38419, hDEPTOR, LOC100359815, LOC102547145, RGD1561030 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DEPTOR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
- DEP
- Domain present in PSD-95, Dlg, and ZO-1/2
- phospholipid binding
- protein serine/threonine kinase inhibitor
- binding protein
- protein kinase inhibitor activity
- canonical PDZ domain
- protein binding
- PDZ domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- prostate cancer
- Alzheimer disease
- idiopathic scoliosis
- interstitial lung disease
- idiopathic pulmonary fibrosis
- chordoma
- bone cancer
role in cell
- apoptosis
- growth
- migration
- phosphorylation in
- expression in
- proliferation
- invasion by
- activation in
- survival
- cell-cell adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DEPTOR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of autophagy
- negative regulation of cell size
- regulation of extrinsic apoptotic signaling pathway
- negative regulation of TOR signaling cascade
- negative regulation of protein kinase activity
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine kinase inhibitor activity
- protein binding
- phosphatidic acid binding
- protein kinase inhibitor activity