MED6 Gene Summary [Human]
Enables transcription coactivator activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of mediator complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MED6 |
| Official Name | mediator complex subunit 6 [Source:HGNC Symbol;Acc:HGNC:19970] |
| Ensembl ID | ENSG00000133997 |
| Bio databases IDs | |
| Aliases | mediator complex subunit 6 |
| Synonyms | 1500012F11Rik, ARC33, AU019660, AV213303, mediator complex subunit 6, NY-REN-28 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MED6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- MED6 mediator sub complex component
- transcription co-activator
- ubiquitin protein ligase activity
- transcription factor binding
- protein binding
- DNA binding
Pathways
Biological processes and signaling networks where the MED6 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by HIV-1
- productive infection by HIV-1
regulates
- DNA endogenous promoter
- RNA polymerase II
- TBP
- DNA promoter
role in cell
- expression in
- cell death
- differentiation
- transactivation in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MED6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription initiation from RNA polymerase II promoter
- somatic stem cell maintenance
- positive regulation of transcription from RNA polymerase II promoter
- protein ubiquitination
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- core mediator complex
- ubiquitin ligase complex
- membrane
- mediator complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- transcription coactivator activity
- transcription coactivator binding