BRPF1 Gene Summary [Human]
This gene encodes a bromodomain, PHD finger and chromo/Tudor-related Pro-Trp-Trp-Pro (PWWP) domain containing protein. The encoded protein is a component of the MOZ/MORF histone acetyltransferase complexes which function as a transcriptional regulators. This protein binds to the catalytic MYST domains of the MOZ and MORF proteins and may play a role in stimulating acetyltransferase and transcriptional activity of the complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Details
| Type | Protein Coding |
| Official Symbol | BRPF1 |
| Official Name | bromodomain and PHD finger containing 1 [Source:HGNC Symbol;Acc:HGNC:14255] |
| Ensembl ID | ENSG00000156983 |
| Bio databases IDs | |
| Aliases | bromodomain and PHD finger containing 1, peregrin, bromodomain-containing protein, 140kD |
| Synonyms | 4833438B11Rik, 4930540D11Rik, BR140, bromodomain and PHD finger containing 1, bromodomain and PHD finger containing, 1, Brpf2, IDDDFP, LOC687462 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BRPF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- transcription regulator
- histone acetyltransferase
- Enhancer of polycomb-like
- PWWP domain
- PWWP (Pro-Trp-Trp-Pro) domain
- protein binding
- Bromodomain
- enzyme activator activity
- PHD-finger
- PHD-like zinc-binding domain
- PHD finger superfamily
- PHD-zinc-finger like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- intellectual developmental disorder with dysmorphic facies and ptosis
- hereditary disorder
- mental retardation
- neurodevelopmental disorder
- global developmental delay
role in cell
- proliferation
- remodeling
- function
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BRPF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of developmental process
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- regulation of transcription, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- MOZ/MORF histone acetyltransferase complex
- plasma membrane
- nucleoplasm
- histone acetyltransferase complex
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding
- acetyltransferase activator activity
- histone acetyltransferase activity (H4-K8 specific)
- histone acetyltransferase activity (H4-K5 specific)
- histone acetyltransferase activity (H4-K12 specific)