ING4 Gene Summary [Human]
This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ING4 |
| Official Name | inhibitor of growth family member 4 [Source:HGNC Symbol;Acc:HGNC:19423] |
| Ensembl ID | ENSG00000111653 |
| Bio databases IDs | |
| Aliases | inhibitor of growth family member 4 |
| Synonyms | D6Wsu147e, D6Xrf92, inhibitor of growth family member 4, inhibitor of growth family, member 4, My036, p29ING4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ING4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- histone binding
- transcription regulator
- histone acetyltransferase
- transcription co-activator
- nuclear localization sequence
- protein binding activity, bridging
- PHD finger superfamily
- Inhibitor of growth (ING) domain family
- protein binding
- Inhibitor of growth proteins N-terminal histone-binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- breast carcinoma
- liver cancer
- small cell lung carcinoma
- small cell lung cancer
- glioma
- glioma formation
- tumorigenesis
- ductal breast carcinoma
role in cell
- migration
- expression in
- cell death
- apoptosis
- differentiation
- proliferation
- cell cycle progression
- transactivation in
- binding in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intermediate filament cytoskeleton
- Cytoplasm
- perinuclear region
- cellular membrane
- cytoplasmic aggregates
- cytosol
- nucleoplasm
- cell membrane leading edge
- lamellipodia
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ING4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of growth
- negative regulation of cell proliferation
- regulation of transcription, DNA-dependent
- protein acetylation
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- regulation of cell growth
- positive regulation of transcription, DNA-dependent
- positive regulation of apoptotic process
- apoptotic process
- regulation of DNA biosynthetic process
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- intermediate filament cytoskeleton
- cytosol
- nucleoplasm
- histone acetyltransferase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- metal ion binding
- methylated histone residue binding
- histone acetyltransferase activity (H4-K16 specific)
- histone acetyltransferase activity (H4-K8 specific)
- histone acetyltransferase activity (H4-K5 specific)
- histone acetyltransferase activity (H4-K12 specific)