Brpf1 Gene Summary [Mouse]
Predicted to enable acetyltransferase activator activity. Predicted to contribute to histone H4K12 acetyltransferase activity; histone H4K5 acetyltransferase activity; and histone H4K8 acetyltransferase activity. Involved in chromatin remodeling. Acts upstream of or within common myeloid progenitor cell proliferation; regulation of fibroblast proliferation; and tube morphogenesis. Predicted to be located in cytosol; nucleus; and plasma membrane. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study syndromic intellectual disability. Orthologous to human BRPF1 (bromodomain and PHD finger containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Brpf1 |
| Official Name | bromodomain and PHD finger containing, 1 [Source:MGI Symbol;Acc:MGI:1926033] |
| Ensembl ID | ENSMUSG00000001632 |
| Bio databases IDs | |
| Aliases | bromodomain and PHD finger containing, 1 |
| Synonyms | 4833438B11Rik, 4930540D11Rik, BR140, bromodomain and PHD finger containing 1, bromodomain and PHD finger containing, 1, Brpf2, IDDDFP, LOC687462 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Brpf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- transcription regulator
- histone acetyltransferase
- Enhancer of polycomb-like
- PWWP domain
- PWWP (Pro-Trp-Trp-Pro) domain
- protein binding
- Bromodomain
- enzyme activator activity
- PHD-finger
- PHD-like zinc-binding domain
- PHD finger superfamily
- PHD-zinc-finger like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- intellectual developmental disorder with dysmorphic facies and ptosis
- hereditary disorder
- mental retardation
- neurodevelopmental disorder
- global developmental delay
role in cell
- proliferation
- remodeling
- function
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Brpf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of developmental process
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- regulation of transcription, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- MOZ/MORF histone acetyltransferase complex
- plasma membrane
- nucleoplasm
- histone acetyltransferase complex
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding
- acetyltransferase activator activity
- histone acetyltransferase activity (H4-K8 specific)
- histone acetyltransferase activity (H4-K5 specific)
- histone acetyltransferase activity (H4-K12 specific)