IL34 Gene Summary [Human]
Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008]
Details
| Type | Protein Coding |
| Official Symbol | IL34 |
| Official Name | interleukin 34 [Source:HGNC Symbol;Acc:HGNC:28529] |
| Ensembl ID | ENSG00000157368 |
| Bio databases IDs | |
| Aliases | interleukin 34 |
| Synonyms | 2010004A03Rik, C16orf77, interleukin 34, RGD1305691 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL34 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- macrophage colony stimulating factor receptor binding
- protein binding
- identical protein binding
- Interleukin 34
Pathways
Biological processes and signaling networks where the IL34 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- Alzheimer disease
- non-insulin-dependent diabetes mellitus
- diabetic nephropathy
- gastroesophageal reflux
- open-angle glaucoma
- Duchenne muscular dystrophy
- acute myeloid leukemia
- osteoporosis
- cutaneous sarcoidosis
role in cell
- expression in
- motility
- phosphorylation in
- number
- proliferation
- differentiation
- development
- activation
- expansion
- clonogenicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL34 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- inflammatory response
- positive regulation of macrophage differentiation
- innate immune response
- positive regulation of protein tyrosine kinase activity
- positive regulation of gene expression
- positive regulation of protein phosphorylation
- positive regulation of macrophage chemotaxis
- positive regulation of cell proliferation
- positive regulation of monocyte differentiation
- positive regulation of oligodendrocyte differentiation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- cytokine activity
- macrophage colony-stimulating factor receptor binding