LIF Gene Summary [Human]
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Details
| Type | Protein Coding |
| Official Symbol | LIF |
| Official Name | LIF interleukin 6 family cytokine [Source:HGNC Symbol;Acc:HGNC:6596] |
| Ensembl ID | ENSG00000128342 |
| Bio databases IDs | |
| Aliases | LIF interleukin 6 family cytokine, differentiation inhibitory activity, differentiation-inducing factor, hepatocyte-stimulating factor III, cholinergic differentiation factor, human interleukin in DA cells |
| Synonyms | CDF, cholinergic differentiation factor, DIA, HILDA, leukaemia inhibitory factor, leukemia inhibitory factor, LIF interleukin 6 family cytokine, LIF, interleukin 6 family cytokine, MLPLI |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LIF often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- leukemia inhibitory factor receptor binding
- receptor binding domain
- LIF / OSM family
- AB loop
- CD loop
- protein binding
- receptor binding
- cytokine
- growth factor
- D helix
Pathways
Biological processes and signaling networks where the LIF gene in human plays a role, providing insight into its function and relevance in health or disease.
- ERK5 Signaling
- Erythropoietin Signaling
- Hematopoiesis from Pluripotent Stem Cells
- Hepatic Cholestasis
- HMGB1 Signaling
- Human Embryonic Stem Cell Pluripotency
- IL-17 Signaling
- Mouse Embryonic Stem Cell Pluripotency
- RAR Activation
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of NFAT in Cardiac Hypertrophy
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Transcriptional Regulatory Network in Embryonic Stem Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- epithelial neoplasia
- cancer
- hypogonadism
- cachexia
- diarrhea
- endometriosis
- systemic lupus erythematosus
- mature T-cell neoplasia
role in cell
- phosphorylation in
- activation in
- accumulation in
- apoptosis
- expression in
- proliferation
- growth
- cell viability
- cell death
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- Nucleus
- Plasma Membrane
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LIF gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lung lobe morphogenesis
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- positive regulation of peptidyl-serine phosphorylation of STAT protein
- lung vasculature development
- decidualization
- positive regulation of astrocyte differentiation
- positive regulation of tyrosine phosphorylation of STAT protein
- positive regulation of transcription from RNA polymerase II promoter
- fibroblast proliferation
- lung alveolus development
- response to hypoxia
- immune response
- stem cell differentiation
- regulation of cell differentiation
- positive regulation of macrophage differentiation
- leukemia inhibitory factor signaling pathway
- trophoblast giant cell differentiation
- positive regulation of fibroblast proliferation
- somatic stem cell maintenance
- positive regulation of cell adhesion mediated by integrin
- regulation of metanephric nephron tubule epithelial cell differentiation
- positive regulation of peptidyl-tyrosine phosphorylation
- macrophage differentiation
- positive regulation of peptidyl-serine phosphorylation
- positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
- cell morphogenesis
- positive regulation of MAPK cascade
- muscle organ morphogenesis
- neuron development
- negative regulation of meiosis
- negative regulation of hormone secretion
- embryo implantation
- blood vessel remodeling
- positive regulation of gene expression
- negative regulation of ERK1 and ERK2 cascade
- gene expression
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytosol
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- cytokine activity
- receptor binding
- leukemia inhibitory factor receptor binding