DPYSL5 Gene Summary [Human]

This gene encodes a member of the CRMP (collapsing response mediator protein) family thought to be involved in neural development. Antibodies to the encoded protein were found in some patients with neurologic symptoms who had paraneoplastic syndrome. A pseudogene of this gene is found on chromosome 11. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

Details

Type
Protein Coding
Official Symbol
DPYSL5
Official Name
dihydropyrimidinase like 5 [Source:HGNC Symbol;Acc:HGNC:20637]
Ensembl ID
ENSG00000157851
Bio databases IDs NCBI: 56896 Ensembl: ENSG00000157851
Aliases dihydropyrimidinase like 5, collapsin response mediator protein 5
Synonyms CRAM, CRMP-5, CV2, dihydropyrimidinase-like 5, DRP-5, LOC100911610, RTSC4, Ulip6
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DPYSL5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • allantoinase
  • Amidohydrolase family
  • enzyme
  • protein binding
  • metallo-dependent_hydrolases
  • D-hydantoinase

Pathways

Biological processes and signaling networks where the DPYSL5 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • prostate cancer
  • venous thromboembolism
  • Ritscher-Schinzel syndrome type 4
  • aortic valve calcification
  • infection by HIV-1
regulated by
  • IL2
  • tretinoin
  • uranyl acetate
  • FES
  • tacrolimus
  • okadaic acid
  • CD3 (complex)
  • cerebellar granule cell
  • NGF
  • cisplatin
regulates
  • tubulin
role in cell
  • quantity
  • growth
  • formation
  • size
  • diameter
  • morphology
  • extension
  • guidance
  • branching in
  • branching

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • soluble fraction
  • membrane fraction
  • glutaminergic synapse
  • cytosol
  • growth cone
  • neurites
  • synapse
  • membrane processes
  • filopodia
  • perikaryon
  • axons
  • dendrites

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human DPYSL5 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • pyrimidine base catabolic process
  • negative regulation of dendrite morphogenesis
  • signal transduction
  • nervous system development
  • axon guidance

Cellular Component

Where in the cell the gene product is active
  • dendrite
  • cytosol
  • macromolecular complex
  • neuronal cell body

Molecular Function

What the gene product does at the molecular level
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
  • protein binding
  • dihydropyrimidinase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.