Dpysl5 Gene Summary [Mouse]
Predicted to enable hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. Predicted to be involved in negative regulation of dendrite morphogenesis. Predicted to act upstream of or within axon guidance. Located in cytoplasm; dendrite; and neuronal cell body. Is active in glutamatergic synapse. Is expressed in several structures, including nervous system; olfactory epithelium; and retina. Human ortholog(s) of this gene implicated in Ritscher-Schinzel syndrome. Orthologous to human DPYSL5 (dihydropyrimidinase like 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dpysl5 |
| Official Name | dihydropyrimidinase-like 5 [Source:MGI Symbol;Acc:MGI:1929772] |
| Ensembl ID | ENSMUSG00000029168 |
| Bio databases IDs | |
| Aliases | dihydropyrimidinase-like 5 |
| Synonyms | CRAM, CRMP-5, CV2, dihydropyrimidinase-like 5, DRP-5, LOC100911610, RTSC4, Ulip6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dpysl5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- allantoinase
- Amidohydrolase family
- enzyme
- protein binding
- metallo-dependent_hydrolases
- D-hydantoinase
Pathways
Biological processes and signaling networks where the Dpysl5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- venous thromboembolism
- Ritscher-Schinzel syndrome type 4
- aortic valve calcification
- infection by HIV-1
regulates
- tubulin
role in cell
- quantity
- growth
- formation
- size
- diameter
- morphology
- extension
- guidance
- branching in
- branching
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- membrane fraction
- glutaminergic synapse
- cytosol
- growth cone
- neurites
- synapse
- membrane processes
- filopodia
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dpysl5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pyrimidine base catabolic process
- negative regulation of dendrite morphogenesis
- signal transduction
- nervous system development
- axon guidance
Cellular Component
Where in the cell the gene product is active
- dendrite
- cytosol
- macromolecular complex
- neuronal cell body
Molecular Function
What the gene product does at the molecular level
- hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
- protein binding
- dihydropyrimidinase activity