MITD1 Gene Summary [Human]
Abscission, the separation of daughter cells at the end of cytokinesis, is effected by endosomal sorting complexes required for transport III (ESCRT-III). The protein encoded by this gene functions as a homodimer, with the N-termini binding to a subset of ESCRT-III subunits and the C-termini binding to membranes. The encoded protein regulates ESCRT-III activity and is required for proper cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Details
| Type | Processed Transcript |
| Official Symbol | MITD1 |
| Official Name | microtubule interacting and trafficking domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25207] |
| Ensembl ID | ENSG00000158411 |
| Bio databases IDs | |
| Aliases | microtubule interacting and trafficking domain containing 1 |
| Synonyms | 1500032H18Rik, microtubule interacting and trafficking domain containing 1, MIT, microtubule interacting and transport, domain containing 1, RGD1307700 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MITD1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Microtubule Interacting and Trafficking molecule domain
- MIT (microtubule interacting and transport) domain
- MIT
- protein domain specific binding
- protein binding
- MIT_C
- identical protein binding
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- midbody
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MITD1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytokinesis after mitosis
- multivesicular body sorting pathway
- negative regulation of protein binding
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- membrane
- midbody
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- identical protein binding
- protein binding
- phosphatidylinositol binding