PLA2G2F Gene Summary [Human]
Enables calcium-dependent phospholipase A2 activity. Involved in glycerophospholipid metabolic process. Predicted to be located in cytosol and extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PLA2G2F |
| Official Name | phospholipase A2 group IIF [Source:HGNC Symbol;Acc:HGNC:30040] |
| Ensembl ID | ENSG00000158786 |
| Bio databases IDs | |
| Aliases | phospholipase A2 group IIF |
| Synonyms | GIIF sPLA2, LOC684551, phospholipase A2 group IIF, phospholipase A2, group IIF, sPLA2-IIF |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLA2G2F often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent phospholipase A2
- enzyme
- protein binding
- phospholipase A2
- PLA2_like
Pathways
Biological processes and signaling networks where the PLA2G2F gene in human plays a role, providing insight into its function and relevance in health or disease.
- Antioxidant Action of Vitamin C
- Atherosclerosis Signaling
- CCR3 Signaling in Eosinophils
- Docosahexaenoic Acid (DHA) Signaling
- Eicosanoid Signaling
- Endothelin-1 Signaling
- ERK/MAPK Signaling
- Fc Epsilon RI Signaling
- Glucocorticoid Receptor Signaling
- MIF Regulation of Innate Immunity
- MIF-mediated Glucocorticoid Regulation
- Neuroinflammation Signaling Pathway
- p38 MAPK Signaling
- Phagosome Formation
- Role of MAPK Signaling in the Pathogenesis of Influenza
- Serotonin Receptor Signaling
- Sperm Motility
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
- epidermal hyperplasia
- skin neoplasia
- contact dermatitis
role in cell
- proliferation
- differentiation
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLA2G2F gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphatidylcholine acyl-chain remodeling
- arachidonic acid secretion
- phosphatidylethanolamine acyl-chain remodeling
- innate immune response
- negative regulation of T cell proliferation
- lipid catabolic process
- phosphatidylserine acyl-chain remodeling
- phosphatidylglycerol acyl-chain remodeling
- phospholipid metabolic process
- arachidonic acid metabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phospholipase A2 activity
- calcium-dependent phospholipase A2 activity
- calcium ion binding
- phospholipid binding