Pla2g2f Gene Summary [Mouse]

Enables phospholipase A2 activity. Involved in arachidonate metabolic process and phosphatidylethanolamine acyl-chain remodeling. Acts upstream of or within negative regulation of T cell proliferation and phospholipid metabolic process. Predicted to be located in extracellular region and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human PLA2G2F (phospholipase A2 group IIF). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Pla2g2f
Official Name
phospholipase A2, group IIF [Source:MGI Symbol;Acc:MGI:1349661]
Ensembl ID
ENSMUSG00000028749
Bio databases IDs NCBI: 26971 Ensembl: ENSMUSG00000028749
Aliases phospholipase A2, group IIF
Synonyms GIIF sPLA2, LOC684551, phospholipase A2 group IIF, phospholipase A2, group IIF, sPLA2-IIF
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pla2g2f often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • calcium-dependent phospholipase A2
  • enzyme
  • protein binding
  • phospholipase A2
  • PLA2_like

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • diabetes mellitus
  • non-insulin-dependent diabetes mellitus
  • epidermal hyperplasia
  • skin neoplasia
  • contact dermatitis
regulated by
  • lipopolysaccharide
  • IL22
  • Immunoglobulin
  • AKT1
  • ADAM17
  • Ca2+
  • 2,4-dinitrophenylhydrazine
  • ELOVL3
  • phytohemagglutinin
regulates
role in cell
  • proliferation
  • differentiation
  • activation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space
  • Plasma Membrane
  • cytosol

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Pla2g2f gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • phosphatidylcholine acyl-chain remodeling
  • arachidonic acid secretion
  • phosphatidylethanolamine acyl-chain remodeling
  • innate immune response
  • negative regulation of T cell proliferation
  • lipid catabolic process
  • phosphatidylserine acyl-chain remodeling
  • phosphatidylglycerol acyl-chain remodeling
  • phospholipid metabolic process
  • arachidonic acid metabolic process

Cellular Component

Where in the cell the gene product is active
  • cytosol
  • extracellular region
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • phospholipase A2 activity
  • calcium-dependent phospholipase A2 activity
  • calcium ion binding
  • phospholipid binding

Gene-Specific Assays for Results You Can Trust

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