CSRP1 Gene Summary [Human]
This gene encodes a member of the cysteine-rich protein (CSRP) family. This gene family includes a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this gene product occurs in proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]
Details
| Type | Protein Coding |
| Official Symbol | CSRP1 |
| Official Name | cysteine and glycine rich protein 1 [Source:HGNC Symbol;Acc:HGNC:2469] |
| Ensembl ID | ENSG00000159176 |
| Bio databases IDs | |
| Aliases | cysteine and glycine rich protein 1 |
| Synonyms | CRP, CRP1, CSRP, CYRP, Cysteine and glycine rich protein 1, D1S181E, HEL-141, HEL-S-286 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CSRP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- preeclampsia
- chronic sinusitis
- organismal death
- congenital heart disease
role in cell
- growth
- aggregation
- formation
- formation in
- growth in
- branching in
- organization
- branching
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- detergent resistant lipid raft fraction
- actin cytoskeleton
- nucleoplasm
- nucleoli
- filopodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CSRP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sarcomere organization
- muscle tissue development
- platelet aggregation
Cellular Component
Where in the cell the gene product is active
- Z disc
- nucleus
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- RNA binding
- structural constituent of muscle
- protein binding
- actinin binding