RGL4 Gene Summary [Human]
This oncogene encodes a protein similar to guanine nucleotide exchange factor Ral guanine dissociation stimulator. Increased expression of this gene leads to translocation of the encoded protein to the cell membrane. The encoded protein can activate several pathways, including the Ras-Raf-MEK-ERK cascade. [provided by RefSeq, Jul 2016]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | RGL4 |
| Official Name | ral guanine nucleotide dissociation stimulator like 4 [Source:HGNC Symbol;Acc:HGNC:31911] |
| Ensembl ID | ENSG00000159496 |
| Bio databases IDs | |
| Aliases | ral guanine nucleotide dissociation stimulator like 4, RalGDS related oncogene |
| Synonyms | Ral-GDS related protein Rgr, ral guanine nucleotide dissociation stimulator like 4, Rgr |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RGL4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- catalytic domain
- RasGEF
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- cancer
- thymus cancer
- lymphoid cancer
- mediastinal cancer
- lymphatic neoplasia
- lymphomagenesis
- thoracic cancer
- hematologic cancer
- hematological neoplasia
regulated by
- EED226
- OSMI-1
- ocifisertib
- MIAT
role in cell
- growth
- development
- contact growth inhibition
- outgrowth
- cell cycle progression
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RGL4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Ras protein signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- guanyl-nucleotide exchange factor activity