RALA Gene Summary [Human]
The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | RALA |
| Official Name | RAS like proto-oncogene A [Source:HGNC Symbol;Acc:HGNC:9839] |
| Ensembl ID | ENSG00000006451 |
| Bio databases IDs | |
| Aliases | RAS like proto-oncogene A, RAS-like protein A, Ras-related protein Ral-A, Ras family small GTP binding protein RALA, ras related GTP binding protein A |
| Synonyms | 3010001O15Rik, HINCONS, RAL, Rasl1, RAS like proto-oncogene A, v-ral simian leukaemia viral oncogene A (ras related), v-ral simian leukemia viral oncogene A (ras related) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RALA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding domain
- ubiquitin protein ligase binding
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- G-protein-coupled receptor binding
- calmodulin binding domain
- GTPase
- enzyme
- geranylgeranylation site
- protein binding
- effector domain
- Ras subfamily of RAS small GTPases
- GTP binding
- myosin binding
- ATPase binding
- ADP-ribosylation factor family
- small GTP-binding protein domain
- CAAX box
- GDP binding
- membrane attachment signal
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the RALA gene in human plays a role, providing insight into its function and relevance in health or disease.
- Agrin Interactions at Neuromuscular Junction
- Angiopoietin Signaling
- Bladder Cancer Signaling
- Chemokine Signaling
- CNTF Signaling
- CXCR4 Signaling
- ErbB Signaling
- ERK5 Signaling
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- Mouse Embryonic Stem Cell Pluripotency
- Neuregulin Signaling
- Neurotrophin/TRK Signaling
- Oncostatin M Signaling
- PDGF Signaling
- PPAR Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Systemic Lupus Erythematosus Signaling
- TGF-β Signaling
- Thyroid Cancer Signaling
- UVC-Induced MAPK Signaling
- VEGF Family Ligand-Receptor Interactions
- α-Adrenergic Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-small cell lung cancer
- cancer
- Hiatt-Neu-Cooper neurodevelopmental syndrome
- lung cancer
- thoracic cancer
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- lung carcinoma process
- epithelial cancer
role in cell
- phosphorylation in
- activation in
- expression in
- migration
- quantity
- phagocytosis by
- differentiation
- proliferation
- formation
- cell proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cytoplasmic vesicle membrane
- cell surface
- cell periphery
- intracellular space
- focal adhesions
- Plasma Membrane
- lysosome
- Mitochondria
- cytosol
- synaptic membrane
- growth cone
- synapse
- cytoplasmic vesicles
- endocytotic vesicle
- GLUT4 vesicles
- membrane rafts
- cleavage furrow
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RALA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- positive regulation of filopodium assembly
- positive regulation of epidermal growth factor receptor signaling pathway
- Ras protein signal transduction
- positive regulation of mitochondrial fission
- exocytosis
- cell division
- chemotaxis
- membrane raft localization
- regulation of actin cytoskeleton organization
- neural tube closure
- establishment of protein localization in mitochondrion
- regulation of exocytosis
- receptor internalization
Cellular Component
Where in the cell the gene product is active
- endocytic vesicle
- cytoplasmic vesicle membrane
- extracellular vesicular exosome
- focal adhesion
- cleavage furrow
- mitochondrion
- synaptic membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- ubiquitin protein ligase binding
- GTPase activity
- small monomeric GTPase activity
- GDP binding
- myosin binding
- Edg-2 lysophosphatidic acid receptor binding
- ATPase binding